OncoMatch

OncoMatch/Pancreatic Cancer (PDAC)/BRCA2

Pancreatic Cancer (PDAC)BRCA2 Clinical Trials

4 recruiting trials·Updated daily from ClinicalTrials.gov

Germline BRCA2 pathogenic variants are the most common hereditary cause of pancreatic cancer (~3–5% of PDAC) and predict sensitivity to platinum-based chemotherapy and PARP inhibition. Olaparib maintenance is FDA-approved for germline BRCA1/2-positive metastatic PDAC with response to first-line platinum. Active trials study PARP inhibitor combinations, somatic BRCA2 eligibility expansion, and neoadjuvant BRCA-targeted strategies.

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Other Pancreatic Cancer (PDAC) biomarkers

Browse other molecular targets with active Pancreatic Cancer (PDAC) trials.

BRCA1KRAS