OncoMatch

OncoMatch/Pancreatic Cancer (PDAC)/BRCA1

Pancreatic Cancer (PDAC)BRCA1 Clinical Trials

4 recruiting trials·Updated daily from ClinicalTrials.gov

Germline BRCA1 pathogenic variants occur in approximately 1–3% of pancreatic ductal adenocarcinoma (PDAC) and confer sensitivity to platinum-based chemotherapy and PARP inhibition through homologous recombination deficiency. Olaparib maintenance after platinum-based induction is FDA-approved for germline BRCA1/2-positive metastatic PDAC. Trials explore PARP inhibitor combinations with ATR/CHK1 inhibitors and immunotherapy, and somatic BRCA1 alteration eligibility.

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BRCA2KRAS