OncoMatch/Brain Cancer — Glioblastoma (GBM)/MGMT promoter methylation
Brain Cancer — Glioblastoma (GBM)MGMT promoter methylation Clinical Trials
MGMT promoter methylation, found in approximately 40–45% of GBM, silences the DNA repair enzyme MGMT and predicts benefit from temozolomide alkylating chemotherapy — the backbone of standard chemoradiation. MGMT-unmethylated GBM has poor response to temozolomide and is the primary population for trials of alternative regimens. Trials investigate temozolomide alternatives, MGMT-independent sensitizers, and combination strategies specifically in MGMT-unmethylated and MGMT-methylated GBM strata.
Top recruiting MGMT promoter methylation Brain Cancer — Glioblastoma (GBM) trials
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A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Ivy Brain Tumor Center
Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma
Severance Hospital
Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy
Oslo University Hospital
INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
Patrick Wen, MD
A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence
Philogen S.p.A.
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
University of California, San Francisco