OncoMatch

OncoMatch/GIST (Gastrointestinal Stromal Tumor)/KIT

GIST (Gastrointestinal Stromal Tumor)KIT Clinical Trials

11 recruiting trials·Updated daily from ClinicalTrials.gov

KIT mutations — predominantly exon 11 deletions and exon 9 insertions — are present in approximately 70–75% of GIST and are the primary therapeutic target. Imatinib is first-line standard; sunitinib, regorafenib, and ripretinib address resistance. Avapritinib is approved for PDGFRA D842V mutations. Trials investigate ripretinib switch maintenance, novel KIT inhibitors for exon 17/18 resistance mutations, and combination strategies for KIT-mutant GIST with secondary resistance.

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Other GIST (Gastrointestinal Stromal Tumor) biomarkers

Browse other molecular targets with active GIST (Gastrointestinal Stromal Tumor) trials.

PDGFRA