OncoMatch

OncoMatch/Colorectal Cancer (CRC)/MSH6

Colorectal Cancer (CRC)MSH6 Clinical Trials

31 recruiting trials·Updated daily from ClinicalTrials.gov

MSH6 loss by IHC defines dMMR status and MSI-H eligibility for checkpoint immunotherapy in colorectal cancer. MSH6 deficiency can result from germline Lynch syndrome mutations or somatic inactivation. Trials for dMMR/MSI-H CRC broadly enroll MSH6-deficient patients, who benefit from pembrolizumab, nivolumab, and combination PD-1/CTLA-4 inhibition.

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Top recruiting

Top recruiting MSH6 Colorectal Cancer (CRC) trials

Ranked by phase and US site count.

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Phase 3

mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Jun Huang

Phase 2/Phase 3

Neoadjuvant Serplulimab & Bevacizumab With FOLFOX vs. FOLFOX Alone in RAS/BRAF WT, pMMR/MSS CRC Patients

Sun Yat-sen University

Phase 3

PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer

Sun Yat-sen University

Phase 2/Phase 3

Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)

Sixth Affiliated Hospital, Sun Yat-sen University

Phase 3

Intermittent or Continuous Panitumumab Plus FOLFIRI for Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancer

National Cancer Institute, Naples

Phase 1/Phase 213 US sites

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

Marengo Therapeutics, Inc.

Additional trials

More MSH6 Colorectal Cancer (CRC) trials

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Phase 2
NCT04165772Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid TumorsPhase 210 US sitesNCT06992258A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal CancerPhase 29 US sitesNCT06529523Tislelizumab in People With Colorectal CancerPhase 21 US siteNCT06959550Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal CancerPhase 21 US siteNCT05411718A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch SyndromePhase 21 US siteNCT06265285Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) ProgramPhase 21 US site
Phase 1
17 international trials (no US sites)
NCT06923345Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)Phase 2NCT06567782A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon CancerPhase 2NCT04920149Mesalamine for Colorectal Cancer Prevention Program in Lynch SyndromePhase 2NCT06856837- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver MetastasesPhase 2NCT07347951A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal CancerPhase 2NCT06698757Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/microsatellite Instability-high, Locally Advanced Colorectal CancerPhase 2NCT06580574Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon CancersPhase 2NCT07068763Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal CancerPhase 2NCT06002789Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCCPhase 2NCT06722183Futibatinib in Combination With (Chemo)Immunotherapy in Colorectal Cancer and Other Solid Tumor EntitiesPhase 2NCT05954429A Study to Explore the Third-line Treatment of Fruquintinib Combined With Serplulimab in Advanced Non-liver-limited Metastatic Colorectal Cancer: a Single-center, Phase 2 StudyPhase 2NCT07279077Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II TrialPhase 2NCT05310643Nivolumab and Ipilimumab in Anti-PD1-Resistant dMMR/MSI mCRCPhase 2NCT06949111Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer（Neo-Color）Phase 2NCT07198165SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARCPhase 2NCT06621173A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α SrRNA in Treating Metastatic CRC PatientsEarly Phase 1NCT07673861Clinical Utility of ctDNA in Detecting Resistance Mechanisms and Delivering Precision Medicine to Cancer PatientsNA
Other Colorectal Cancer (CRC) biomarkers

Browse other molecular targets with active Colorectal Cancer (CRC) trials.

KRASNRASBRAFMSH2MMR / MSI-HPMS2MLH1HER2 (ERBB2)EGFR
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