OncoMatch/Bile Duct Cancer (Cholangiocarcinoma)/IDH1
Bile Duct Cancer (Cholangiocarcinoma)IDH1 Clinical Trials
IDH1 mutations occur in approximately 15–20% of intrahepatic cholangiocarcinoma and produce the oncometabolite 2-hydroxyglutarate (2-HG), driving epigenetic dysregulation. Ivosidenib is FDA-approved for previously treated IDH1-mutant advanced cholangiocarcinoma (ClarIDHy trial). Trials investigate ivosidenib combinations with PD-1 inhibitors and chemotherapy, and pan-IDH inhibitors covering both IDH1 and IDH2 mutations.
Top recruiting IDH1 Bile Duct Cancer (Cholangiocarcinoma) trials
Ranked by phase and US site count.
See all trials matched to your profile →An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy.
Peking Union Medical College Hospital
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies
Rigel Pharmaceuticals
Clinical Utility of ctDNA in Detecting Resistance Mechanisms and Delivering Precision Medicine to Cancer Patients
Royal Marsden NHS Foundation Trust
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