OncoMatch/Clinical Trials/NCT07859488
Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery
Official title: Perioperative Melatonin and Other Neuroinflammatory Biomarkers for Predicting Postoperative Delirium in Older Adults Undergoing Elective Abdominal Cancer Surgery
Is NCT07859488 recruiting? Yes, currently enrolling (Oct 2026).
This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer surgery. The study will also evaluate serotonin, kynurenine, kynurenic acid, and vitamin B12 as potential biomarkers associated with postoperative delirium. Participants will undergo routine standardized general anesthesia and thoracic epidural analgesia. Venous blood samples will be obtained preoperatively and on postoperative day 3. In participants who develop delirium, an additional blood sample will be obtained as soon as possible after delirium is detected. Postoperative delirium will be assessed using the Confusion Assessment Method (CAM) on postoperative days 1, 3, and 5. No experimental drug or additional therapeutic intervention will be administered as part of the study.
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Performance status
ASA 2–3
Demographics
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Frequently asked questions
Is NCT07859488 currently recruiting?
Yes, this trial is currently recruiting patients.
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