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OncoMatch/Clinical Trials/NCT07801287

Iparomlimab/Tuvonralimab Plus SBRT and Lenvatinib for Perioperative Treatment of Potentially Resectable Intermediate-Stage HCC

Is NCT07801287 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies Iparomlimab/Tuvonralimab plus SBRT and Lenvatinib for hcc - hepatocellular carcinoma.

Phase 2RecruitingTianjin Medical University Cancer Institute and HospitalNCT07801287Data as of Sep 2026Location: China

Treatment: Iparomlimab/Tuvonralimab plus SBRT and LenvatinibThis study aims to evaluate the efficacy and safety of Iparomlimab and Tuvonralimab (the combination antibody) combined with SBRT and Lenvatinib in the perioperative treatment of patients with potentially resectable intermediate-stage hepatocellular carcinoma.. The objective is to explore potential survival benefits for this population and provide patients with more effective treatment options.

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Extracted eligibility criteria

Treatments studied

Targeted therapy

Iparomlimab/Tuvonralimab plus SBRT and Lenvatinib

Cancer type

Hepatocellular Carcinoma

Disease stage

Required: Stage IIIA

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

Adequate bone marrow function within 7 days prior to the first administration of study drug

Liver function

Child-Pugh score <7

Child-Pugh score <7; Adequate organ and bone marrow function within 7 days prior to the first administration of study drug

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT07801287 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

What disease stage is eligible?

Stage IIIA is required.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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