OncoMatch/Clinical Trials/NCT07776353
Understanding New Cachexia Subtypes Through Observational Epidemiological Research
Is NCT07776353 recruiting? Yes, currently enrolling (Sep 2026).
The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung cancer, pancreatic adenocarcinoma, or colorectal cancer will be enrolled, as these malignancies carry a substantial risk of cancer cachexia, which is characterized by progressive loss of weight, muscle, and adipose tissue, accompanied by functional decline and reduced quality of life. Data collected includes demographic, physiologic, and clinical data, including tumor characteristics and biomarkers of inflammation, hormonal and metabolic status, body composition, physical function, and patient reported outcomes. Investigators will identify patient phenotypes (i.e., subgroups) that may reflect distinct biological or clinical pathways underlying cancer cachexia. By characterizing heterogeneity in cancer cachexia, this study aims to inform the development of improved diagnostic criteria and more targeted therapeutic strategies, ultimately enhancing clinical trial design and supportive care for patients with advanced colorectal, lung, or pancreatic cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Non-Small Cell Lung Carcinoma
Pancreatic Cancer
Disease stage
Required: Stage IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy or surgery for separate primary cancer
Exception: non-melanoma skin cancer
Have received chemotherapy or surgery for separate primary cancer within the past 3 years other than non-melanoma skin cancer
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Kaiser Permanente Northern California · Pleasanton, California
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT07776353 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior chemotherapy or surgery for separate primary cancer disqualifies patients from enrollment.
What disease stage is eligible?
Stage IV is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify