OncoMatch/Clinical Trials/NCT07755449
CLEAR (Cervical Lymphatic Exclusion in Adjuvant Radiation)
Is NCT07755449 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies non-drug interventions for locally advanced head and neck squamous cell carcinoma.
The goal of this clinical trial is to learn if selectively omitting postoperative cervical irradiation is a safe and feasible treatment strategy for patients with resected, locally advanced squamous cell carcinoma of the head and neck (HNSCC) who underwent systematic neck dissection and have no high-risk nodal factors. The main questions it aims to answer are: * Is the regional recurrence rate with selective omission of postoperative cervical irradiation non-inferior to the recurrence rate reported with standard complete nodal irradiation (6-8%)? * Does selective omission of postoperative cervical irradiation reduce toxicity? * Does selective omission of postoperative cervical irradiation improve immunological preservation and quality of life? Researchers will compare outcomes in participants treated with this selective irradiation strategy to previously published data and to a retrospective institutional cohort treated with standard complete nodal irradiation, to see if it maintains regional control while reducing toxicity and preserving immune function and quality of life. Participants will: * Receive postoperative radiotherapy according to the new protocol, omitting irradiation of low-risk nodal levels * Receive concomitant chemotherapy if clinically indicated, per standard practice * Visit for checkups, blood sample collection, to complete quality-of-life questionnaires and attend follow-up visits over 48 months
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Disease stage
Required: Stage PT1N1, PT2N1, PT3N0, PT3N1, PT4N0, PT4N1
Stages pT1-pT2N1 and pT3-pT4N0/N1. If N1, all of the following criteria must be met: presence of a single cervical lymph node without extracapsular extension, diameter < 1 cm, and no skip metastasis
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: irradiation to the head and neck region
Prior irradiation to the head and neck region
Cannot have received: surgery in the head and neck region
Prior surgery in the head and neck region
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07755449 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior irradiation to the head and neck region, surgery in the head and neck region disqualifies patients from enrollment.
What disease stage is eligible?
Stage PT1N1 or PT2N1 or PT3N0 or PT3N1 or PT4N0 or PT4N1 is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages