OncoMatch/Clinical Trials/NCT07753499
Trophoblast Cell-Surface Antigen 2 (Trop-2) Targeted PET/CT in Recurrent and Metastatic Thyroid Cancer
Is NCT07753499 recruiting? Yes, currently enrolling (Sep 2026). This NA trial studies non-drug interventions for tumor.
In this study, we comprehensively evaluated the clinical utility of Trop2 PET/CT (68Ga-MY6349 PET/CT) imaging for detecting recurrent and metastatic thyroid cancer, and the results were compared with those of 68Ga-FAPI PET/CT. The primary objective of this study was to evaluate the patient-based sensitivity of 68Ga-MY6349 PET/CT in detecting recurrent and metastatic thyroid cancer. The secondary objectives included its overall specificity, lesion-based diagnostic performance, comparative tumor uptake relative to 68Ga-FAPI PET/CT, and the impact on clinical management.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Thyroid Gland Carcinoma
Biomarker criteria
Required: TG expression (Tgon ≥1 ng/mL after 131I ablation or ≥5 ng/mL without ablation)
elevated thyrotropin suppressed thyroglobulin (Tgon ≥1 ng/mL after 131I ablation or ≥5 ng/mL without ablation) with negative anti thyroglobulin antibodies (<20 IU/mL) for DTC and HGFCTC
Required: CALCA expression (calcitonin >10 pg/mL)
elevated calcitonin (>10 pg/mL) for MTC
Disease stage
Metastatic disease required
recurrent and metastatic thyroid cancer
Demographics
Prior therapy
Must have received: thyroidectomy
DTC and HGFCTC following thyroidectomy with or without 131I therapy, MTC after thyroidectomy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07753499 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received thyroidectomy.
Does this trial require TG?
Yes, TG expression is a required biomarker for enrollment.
Does this trial require CALCA?
Yes, CALCA expression is a required biomarker for enrollment.
Is there an age limit?
Yes. Patients must be 90 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages