OncoMatch/Clinical Trials/NCT07743112
A Phase 2 Study of MAX-40279 Combined With Venetoclax and Azacitidine in Unfit Newly Diagnosed Acute Myeloid Leukemia
Is NCT07743112 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies multiple treatments including MAX-40279 and Azacitidine for acute myeloid leukemia.
Treatment: MAX-40279 · Azacitidine · Venetoclax — This is a prospective, multicenter, phase Ⅱ study consisting of dose escalation and ex-pansion stages in unfit newly diagnosed AML.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Targeted therapy
Chemotherapy
Other
Cancer type
Acute Myeloid Leukemia
Biomarker criteria
Excluded: ABL1 bcr-abl1 fusion
Performance status
ECOG 0–3(Limited self-care)
Prior therapy
Lab requirements
Blood counts
WBC ≤3×10^9/L
Kidney function
Serum creatinine clearance ≥30 mL/min (measured or calculated); Creatinine clearance ≥30 mL/min but ≤45 mL/min (Cockcroft-Gault)
Liver function
AST/ALT/ALP ≤3×ULN (except: due to leukemic involvement); Total bilirubin ≤1.5×ULN
Cardiac function
History of chronic heart failure (CHF) requiring treatment or left ventricular ejection fraction (LVEF) ≤50%
WBC≤3×10^9/L、AST/ALT/ALP ≤3×ULN (except: due to leukemic involvement)、Total bilirubin ≤1.5×ULN、Serum creatinine clearance ≥30 mL/min (measured or calculated); History of chronic heart failure (CHF) requiring treatment or left ventricular ejection fraction (LVEF) ≤50%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07743112 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Are patients with ABL1 alterations eligible?
No. ABL1 bcr-abl1 fusion is an exclusion criterion.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages