OncoMatch/Clinical Trials/NCT07654166

Tissue Adhesive Versus Sutures in Oral Biopsy Closure

Official title: Comparison of Tissue Adhesive and Surgical Sutures for Wound Closure After Oral Excisional Biopsies: A Randomized Controlled Clinical Trial

Is NCT07654166 recruiting? Yes, currently enrolling (Oct 2026). This NA trial studies multiple treatments including Tissue adhesive (PeriAcryl 90 HV) and Surgical suture (Nylon 4-0) for mouth neoplasms.

Treatment: Tissue adhesive (PeriAcryl 90 HV) · Surgical suture (Nylon 4-0) — Excisional biopsies are commonly performed in the oral mucosa, and proper wound closure and hemostasis are critical for the success of the surgical procedure. Suturing remains the gold standard for closing surgical incisions; however, it has several drawbacks, including being time-consuming and requiring technical skill for proper placement. In addition, access to posterior areas of the oral cavity can be challenging. Suturing may also cause patient discomfort during needle penetration of tissues and can serve as a potential pathway for microbial contamination. Therefore, this randomized controlled clinical trial aims to evaluate one of the latest tissue adhesives from the cyanoacrylate group (PeriAcryl 90 HV) compared to conventional surgical sutures (Nylon 4-0) for wound closure following oral excisional biopsies. A total of 28 patients with oral fibroma will be randomly assigned to either the tissue adhesive group or the suture group (14 patients per group).