OncoMatch/Clinical Trials/NCT07630961
Phase I Study of JFI447 [68Ga]Ga-DFC413 and Comparison to FFG233 [68Ga]Ga-NNS309 in Patients With Solid Tumors
Is NCT07630961 recruiting? Yes, currently enrolling (Jul 2026). This Phase 1 trial studies multiple treatments including 68Ga-DFC413 and 68Ga-NNS309 for metastatic pancreatic ductal adenocarcinoma (pdac).
Treatment: 68Ga-DFC413 · 68Ga-NNS309 — The purpose of Part 1 of this study is to evaluate the imaging characteristics, safety, biodistribution and pharmacokinetics of \[68Ga\]Ga-DFC413, and in Part 2 compare to \[68Ga\]Ga-NNS309 in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), HR+/HER2- ductal and lobular breast cancer (BC), triple negative breast cancer (TNBC), colorectal cancer (CRC), and soft tissue sarcoma (STS). In Part 2 of this study (comparison of \[68Ga\]Ga-DFC413 and \[68Ga\]Ga-NNS309), not all indications might be explored.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Pancreatic Cancer
Non-Small Cell Lung Carcinoma
Triple-Negative Breast Cancer
Breast Carcinoma
Colorectal Cancer
Sarcoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
ANC ≥ 1.0 x 10^9/L; Hemoglobin ≥ 9 g/dL; Platelet count ≥ 75 x 10^9/L
Kidney function
eGFR ≥ 60 mL/min (CKD-EPI 2021 or 24-hour urine)
Liver function
Total bilirubin ≤ 1.5 x ULN (except Gilbert's syndrome ≤ 3.0 x ULN); direct bilirubin ≤ 1.5 x ULN; ALT ≤ 3.0 x ULN (≤ 5.0 x ULN with liver involvement); AST ≤ 3.0 x ULN (≤ 5.0 x ULN with liver involvement)
Out-of-range laboratory values defined as: eGFR < 60 mL/min; Total bilirubin > 1.5 x ULN (except Gilbert's syndrome > 3.0 x ULN); direct bilirubin > 1.5 x ULN; ALT > 3.0 x ULN (except with liver involvement > 5.0 x ULN); AST > 3.0 x ULN (except with liver involvement > 5.0 x ULN); ANC < 1.0 x 10^9/L; Hemoglobin < 9 g/dL; Platelet count < 75 x 10^9/L
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07630961 currently recruiting?
Yes, this trial is currently recruiting patients.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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