OncoMatch/Clinical Trials/NCT07493148

Chidamide Combination With R-mini CHOP Followed by Chidamide+CD20 Maintenance in Elderly Newly Diagnosed MYC/BCL2+ DLBCL

Is NCT07493148 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for diffuse large b-cell lymphoma (dlbcl).

Phase 2RecruitingOu Bai, MD/PHDNCT07493148Data as of May 2026

Treatment: Chidamide · Rituximab · Cyclophosphamide · Doxorubicin · Vincristine · Prednisone · Chidamide + Rituximab maintenance — Efficacy and safety of chidamide in combination with the R-mini CHOP regimen, followed by chidamide plus CD20 monoclonal antibody as maintenance therapy, in elderly patients with newly diagnosed MYC/BCL2 double-expressor DLBCL.

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Extracted eligibility criteria

Cancer type

Diffuse Large B-Cell Lymphoma

Non-Hodgkin Lymphoma

Biomarker criteria

Required: CD20 overexpression (positive)

CD20-positive

Required: MYC overexpression (≥ 40%)

MYC/BCL2 double-expressor: Immunohistochemistry (IHC) per WHO criteria: MYC ≥ 40%, and BCL2 ≥ 50%

Required: BCL2 overexpression (≥ 50%)

MYC/BCL2 double-expressor: Immunohistochemistry (IHC) per WHO criteria: MYC ≥ 40%, and BCL2 ≥ 50%

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)

Max 0 prior lines

Lab requirements

Blood counts

Hemoglobin (Hb) ≥ 90 g/L, Absolute neutrophil count (ANC) ≥ 1.5 × 10⁹/L, Platelet count (PLT) ≥ 90 × 10⁹/L

Kidney function

Serum creatinine (Cr) ≤ 1.5 × upper limit of normal (ULN)

Liver function

Total bilirubin (TBIL) ≤ 1.5 × ULN; ALT and AST ≤ 2.5 × ULN (≤ 5 × ULN in cases of liver metastasis)

Hematology: Hemoglobin (Hb) ≥ 90 g/L, Absolute neutrophil count (ANC) ≥ 1.5 × 10⁹/L, Platelet count (PLT) ≥ 90 × 10⁹/L; Biochemistry: Serum creatinine (Cr) ≤ 1.5 × ULN; Total bilirubin (TBIL) ≤ 1.5 × ULN; ALT and AST ≤ 2.5 × ULN (≤ 5 × ULN in cases of liver metastasis)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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