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OncoMatch/Clinical Trials/NCT07472153

PD-1 (Programmed Death-1) Versus PD-L1 (Programmed Death-ligand 1) Immune Check Point Inhibitors Combined With Chemotherapy, With or Without Bevacizumab, In Patients With Metastatic, Persistent Or Recurrent Cervical Cancer

Is NCT07472153 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments including PD-1 antibody and PD-L1 antibody for metastatic cervical cancer.

Phase 2/3RecruitingN.N. Alexandrov National Cancer CentreNCT07472153Data as of May 2026

Treatment: PD-1 antibody · PD-L1 antibody · Chemotherapy and bevacizumab (CT-BEV)This is a randomized trial evaluating the results of using of PD-1 and PD-L1 immune checkpoint inhibitors combined with chemotherapy, with or without bevacizumab, in patients with metastatic, persistent, and recurrent cervical cancer.

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Extracted eligibility criteria

Cancer type

Cervical Cancer

Biomarker criteria

Required: PD-L1 (CD274) any tested (testing required; no eligibility threshold specified)

Disease stage

Required: Stage IVB, IIB, IIIA, IIIB, IVA, IA (FIGO 2018)

Metastatic cervical cancer (stage IVB according to FIGO (International Federation of Gynaecology and Obstetrics) 2018); Persistent cervical cancer (primary incurability after radical treatment for stages IIB-IVA cervical cancer according to FIGO 2018); Reccurent cervical cancer (first recurrence after completed radical treatment for IA-IVB cervical cancer according to FIGO 2018)

Performance status

ECOG 0–1(Restricted strenuous activity)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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