OncoMatch/Clinical Trials/NCT07435376
Intra-lesional Tumor Boost for Bulky Cervical Cancer
Is NCT07435376 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for cervical cancer.
The goal of this clinical trial is to learn if adding a radiation boost (intra-lesional boost) works to treat patients with large-sized cervical cancer. It will also learn about the safety of this treatment. The main questions it aims to answer are: * Does the extra radiation boost effectively reduce the tumor size before the internal radiation (brachytherapy) treatment begins? * What medical problems (side effects) do participants have when receiving this treatment? Researchers will give this intra-lesional boost to all participants during their standard radiation therapy to see if it helps shrink the tumor more than usual. Participants will: * Receive radiation therapy to the pelvis with a targeted boost to the tumor for about 5 to 6 weeks * Visit the clinic daily for radiation treatment and regularly for checkups Have an MRI scan during the 4th or 5th week of treatment to measure the tumor size * Receive internal radiation therapy (brachytherapy) after finishing the external radiation * Visit the clinic for follow-up checkups and tests for up to 2 years
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy
Exception: neoadjuvant chemotherapy before radiation therapy
Patients who have received prior chemotherapy (neoadjuvant chemotherapy) before radiation therapy
Cannot have received: radiation therapy
Exception: prior history of radiation therapy to the abdomen or pelvis
Patients with prior history of radiation therapy to the abdomen or pelvis
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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