OncoMatch/Clinical Trials/NCT07435376
Intra-lesional Tumor Boost for Bulky Cervical Cancer
Is NCT07435376 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies non-drug interventions for cervical cancer.
The goal of this clinical trial is to learn if adding a radiation boost (intra-lesional boost) works to treat patients with large-sized cervical cancer. It will also learn about the safety of this treatment. The main questions it aims to answer are: * Does the extra radiation boost effectively reduce the tumor size before the internal radiation (brachytherapy) treatment begins? * What medical problems (side effects) do participants have when receiving this treatment? Researchers will give this intra-lesional boost to all participants during their standard radiation therapy to see if it helps shrink the tumor more than usual. Participants will: * Receive radiation therapy to the pelvis with a targeted boost to the tumor for about 5 to 6 weeks * Visit the clinic daily for radiation treatment and regularly for checkups Have an MRI scan during the 4th or 5th week of treatment to measure the tumor size * Receive internal radiation therapy (brachytherapy) after finishing the external radiation * Visit the clinic for follow-up checkups and tests for up to 2 years
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Cannot have received: chemotherapy
Exception: neoadjuvant chemotherapy before radiation therapy
Patients who have received prior chemotherapy (neoadjuvant chemotherapy) before radiation therapy
Cannot have received: radiation therapy
Exception: prior history of radiation therapy to the abdomen or pelvis
Patients with prior history of radiation therapy to the abdomen or pelvis
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07435376 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior chemotherapy, radiation therapy disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 80 years or younger and at least 19 years old.
Is this trial open to male patients?
No. This trial enrolls female patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages