OncoMatch/Clinical Trials/NCT07432399
Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)
Is NCT07432399 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Lidocaine and Dexamethasone for colon cancer.
Treatment: Lidocaine · Dexamethasone — This study is a prospective, randomized, double-blind, phase II interventional clinical trial evaluating the effect of perioperative intravenous lidocaine infusion compared with high-dose dexamethasone on postoperative immune response and clinical outcomes in patients undergoing surgery for colon cancer. Patients with colon cancer often experience postoperative inflammatory and immune changes that may influence recovery and complications. The aim of this study is to assess whether perioperative lidocaine infusion may improve postoperative immune function and clinical recovery compared with standard perioperative anti-inflammatory treatment. Participants will be randomly assigned to receive either intravenous lidocaine infusion or high-dose dexamethasone during the perioperative period. Immune response markers and postoperative clinical outcomes will be evaluated. The results of this trial may contribute to improved perioperative management and recovery strategies for patients undergoing surgery for colon cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Lab requirements
Kidney function
Severe renal impairment [excluded]
Liver function
Severe hepatic impairment [excluded]
Cardiac function
Severe cardiac conduction disorders or clinically significant arrhythmias [excluded]
Severe hepatic impairment; Severe renal impairment; Severe cardiac conduction disorders or clinically significant arrhythmias [excluded]
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