OncoMatch/Clinical Trials/NCT07379476
Local Ablative Therapy to Oligoresidual Metastasis in EGFR Mutated Non-small Cell Lung Cancer
Is NCT07379476 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Osimertinib alone for lung cancer (nsclc).
Treatment: Osimertinib alone — This is an open-label, multicentre, randomized phase II clinical trial. Patients with stage IV (AJCC 9th edition) non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or exon 21 L858R mutation, who had less than or equal to 3 active oligoresidual cancer sites amenable to local ablative therapy (LAT) (as determined by physician) after 3-6 months of firstline osimertinib treatment, are eligible. Subjects will be randomized 1:1 to osimertinib with or without LAT.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: EGFR exon 19 deletion
Required: EGFR l858r
Disease stage
Required: Stage IV
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: EGFR tyrosine kinase inhibitor (osimertinib) — first line for stage IV disease
Receive first line osimertinib monotherapy for stage IV disease
Lab requirements
Blood counts
haemoglobin ≥9.0g/dL, absolute neutreophil count ≥1.0 x 10^9/L, platelet count ≥100 x 10^9/L
Kidney function
creatinine clearance ≥30ml/min, according to the formula of Cockcroft-Gault equation
Liver function
bilirubin ≤1.5 x ULN, AST/ALT ≤2.5 x ULN
Adequate haematological values: haemoglobin ≥9.0g/dL, absolute neutreophil count ≥1.0 x 10^9/L, platelet count ≥100 x 10^9/L; Adequate hepatic function: bilirubin ≤1.5 x ULN, AST/ALT ≤2.5 x ULN; Adequate renal function: creatinine clearance ≥30ml/min, according to the formula of Cockcroft-Gault equation
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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