OncoMatch/Clinical Trials/NCT07373964
A Prospective, Single-Arm, Single-Center Phase II Study Evaluating the Efficacy and Safety of Chidamide Combined With PD-L1 Inhibitor, Carboplatin, and Etoposide as First-Line Treatment in Patients With Extensive-Stage Small-Cell Lung Cancer (ES-SCLC)
Is NCT07373964 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Chidamide Tablets； PD-L1 Inhibitor (as per chosen drug's prescribing information)；Carboplatin； Etoposide for small cell lung cancer.
Treatment: Chidamide Tablets； PD-L1 Inhibitor (as per chosen drug's prescribing information)；Carboplatin； Etoposide — This is a Phase II, single-arm, single-center study evaluating Chidamide combined with a PD-L1 inhibitor, carboplatin, and etoposide as first-line therapy in extensive-stage small-cell lung cancer (ES-SCLC) patients. The primary objective is to assess Progression-Free Survival (PFS) per RECIST v1.1. Secondary objectives include Objective Response Rate (ORR), Disease Control Rate (DCR), Duration of Response (DOR), Overall Survival (OS), and safety. Approximately 36 participants will receive induction therapy (Chidamide + chemotherapy + PD-L1 inhibitor) for 4 cycles, followed by Chidamide maintenance until progression or unacceptable toxicity.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Disease stage
Required: Stage IV
Histologically confirmed ES-SCLC, unsuitable for local radical therapy
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: hdac inhibitor
Cannot have received: immune checkpoint inhibitor
Lab requirements
Blood counts
adequate hematological function
Kidney function
adequate renal function
Liver function
adequate hepatic function
Cardiac function
adequate cardiac function; QTc ≤450 ms
Adequate organ function (hematological, hepatic, renal, cardiac). Uncontrolled cardiovascular disease or QTc >450 ms [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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