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OncoMatch/Clinical Trials/NCT07337876

Organ Preservation in Rectal Cancer by Dose Escalated MR Guided Adaptive Radiotherapy

Is NCT07337876 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for rectal cancer.

Phase 2RecruitingUniversity Hospital TuebingenNCT07337876Data as of May 2026

This study is testing whether radiation delivered with MRI guidance using a so-called MR-linac in distal rectal cancer can result in a high rate of organ preservation. Patients will receive radiotherapy together with standard chemotherapy.

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Performance status

WHO/ECOG 0–1

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: antineoplastic therapy

Prior antineoplastic therapy for rectal cancer

Cannot have received: radiotherapy

Prior radiotherapy of the pelvic region

Lab requirements

Blood counts

adequate hematological function parameters

Kidney function

adequate renal function parameters

Liver function

adequate hepatic function parameters

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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