OncoMatch/Clinical Trials/NCT07333274
Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Is NCT07333274 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Nimotuzumab for head & neck squamous cell carcinoma.
Treatment: Nimotuzumab — This is an open-label, prospective, randomized, Phase III, international multicenter clinical study to compare radiotherapy plus nimotuzumab versus radiotherapy alone in platinum-ineligible patients with locoregionally advanced head and neck squamous cell carcinoma (LA-HNSCC),
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: EGFR testing required if tissue available (testing required; no eligibility threshold specified)
Provide tumor tissue, whenever possible, for EGFR testing
Required: HPV testing required for oropharyngeal cancer if tissue available (testing required; no eligibility threshold specified)
for oropharyngeal cancer, provide tissue for HPV/p16 testing if feasible
Disease stage
Required: Stage III, IVA, IVB
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: pd-1 inhibitor
Exception: within 4 weeks prior to enrollment
Cannot have received: egfr monoclonal antibody
Exception: within 4 weeks prior to enrollment
Cannot have received: egfr tyrosine kinase inhibitor
Exception: within 4 weeks prior to enrollment
Cannot have received: anti-angiogenic agent
Exception: within 4 weeks prior to enrollment
Lab requirements
Blood counts
wbc ≥4×10^9/l; absolute neutrophil count ≥1.5×10^9/l; platelets ≥100×10^9/l; hemoglobin ≥90 g/l
Kidney function
serum creatinine ≤1.5×uln or crcl ≥60 ml/min (cockcroft-gault)
Liver function
total bilirubin ≤1.5×uln; ast ≤2.5×uln; alt ≤2.5×uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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