OncoMatch/Clinical Trials/NCT07322094
CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer
Is NCT07322094 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including TORL-1-23 and paclitaxel and TORL-1-23 and carboplatin for figo stage iii and iv ovarian cancer.
Treatment: TORL-1-23 and paclitaxel · TORL-1-23 and carboplatin · TORL-1-23, paclitaxel, and carboplatin — A Phase 1B/2 Study to Investigate the Safety and Efficacy of TORL-1-23 with Chemotherapy Given Before Initial Surgery in Women with Advanced Stage Ovarian Cancer
Check if I qualifyExtracted eligibility criteria
Cancer type
Ovarian Cancer
Biomarker criteria
Required: CLDN6 overexpression
Positive for claudin 6 (CLDN6) expression
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: systemic therapy
Prior systemic treatment for the disease under study
Cannot have received: surgery
Prior surgery
Cannot have received: radiation therapy
Prior radiation therapy to the abdomen or pelvis
Cannot have received: chemotherapy
Exception: within 5-half-lives of C1D1
Current recipient or receipt within 5-half-lives of C1D1 of chemotherapy, biologic/targeted therapy, immunomodulator therapy for any disease indication
Cannot have received: biologic/targeted therapy
Exception: within 5-half-lives of C1D1
Current recipient or receipt within 5-half-lives of C1D1 of chemotherapy, biologic/targeted therapy, immunomodulator therapy for any disease indication
Cannot have received: immunomodulator therapy
Exception: within 5-half-lives of C1D1
Current recipient or receipt within 5-half-lives of C1D1 of chemotherapy, biologic/targeted therapy, immunomodulator therapy for any disease indication
Lab requirements
Blood counts
Kidney function
Liver function
Adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UCLA · Los Angeles, California
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