OncoMatch/Clinical Trials/NCT07319871
A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer
Is NCT07319871 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Pasritamig and JNJ-86974680 for prostatic neoplasms.
Treatment: Pasritamig · JNJ-86974680 — The purpose of this study is to identify the recommended phase 2 combination dose (RP2CD) of Pasritamig in combination with JNJ-86974680 in Part 1 (Dose finding) of the study and to determine how safe and tolerable the RP2CD is for treatment of participants with advanced prostate cancer in Part 2 (Dose expansion) of study.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Biomarker criteria
Required: KLK3 PSA ≥ 2 ng/mL (≥ 2 ng/mL)
Prostate-specific antigen (PSA) greater than or equal to (≥) 2 nanograms per milliliters (ng/mL) at screening
Disease stage
Required: Stage METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Metastatic disease required
Metastatic castration-resistant prostate cancer (mCRPC) that is metastatic either to bone, any lymph node, or both without clear evidence of metastasis to visceral organs. Local-regional invasion (rectum, bladder) and bone disease with soft tissue component can be included
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: androgen deprivation therapy (orchiectomy, gonadotropin-releasing hormone (GnRH) analog (agonist or antagonist)) — ongoing
Prior orchiectomy or medical castration (for example, must be receiving ongoing androgen deprivation therapy with a gonadotropin-releasing hormone [GnRH] analog [agonist or antagonist] prior to the first dose of study drug and must continue this therapy throughout the treatment phase)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Florida Cancer Specialists · Sarasota, Florida
- Columbia University Medical Center · New York, New York
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