OncoMatch/Clinical Trials/NCT07300683
Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma
Is NCT07300683 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies CARCCR9 T cells for t cell acute lymphoblastic leukemia.
Treatment: CARCCR9 T cells — The goal of this clinical trial is to learn if anti-CCR9 CAR T cells (which will be made using the patient's own blood cells) are safe and which dose should be used in children and adults with T cell leukaemia and lymphoma. Participants will: * have T cells collected from their blood and these T cells will be used to make the CAR-T cells in a specialized laboratory. * be admitted at the hospital a week before the CAR T cells infusion to receive a short course of chemotherapy drugs which prepare the body to receive the CAR T cells. * be given the CAR T cells into their vein. * stay in the hospital for a minimum of 2 weeks to be closely monitored * following discharge, participants will come to the clinic for check-ups (approximately 12 visits in the first two years) * during screening, treatment and follow up visits, participants will have physical examination, collection of blood samples and bone marrow biopsies and/or imaging tests (CT/PET-CT scans) depending on their type of T-cell cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Lymphoblastic Leukemia
Non-Hodgkin Lymphoma
Biomarker criteria
Required: CCR9 positive disease as assessed by flow cytometry
CCR9-positive disease as assessed by flow cytometry
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: combination cytotoxic chemotherapy
Relapsed or refractory T-ALL/T-LBL following at least one (≥18 years old) or two (<18 years old) standard prior lines of combination cytotoxic therapy
Lab requirements
Kidney function
gfr <30 ml/min
Liver function
bilirubin >3 x upper limit of normal
Cardiac function
cardiac dysfunction
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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