OncoMatch/Clinical Trials/NCT07296484
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Is NCT07296484 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies clofutriben for type 2 diabetes.
Treatment: clofutriben — CAPTAIN-T2D will take place in two parts. Part 1 (Screening) will evaluate patients with type 2 diabetes and elevated cortisol risk factors for trial eligibility and the presence of elevated cortisol. Participants deemed eligible from Part 1 will be randomized to either clofutriben or placebo in the double-blind (participant and investigator), dose-ranging, interventional Part 2 (Treatment).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Prior therapy
Must have received: antidiabetic medication
Treatment with stable and adequate doses of ≥2 injectable or oral ADMs. (An ADM will be deemed stable if the dose has been the same for at least 3 months prior to Screening 1 and without change between Screening 1 and Day 1) (An ADM dose will be deemed adequate if it is at or above the maximal labelled dose, or a sub-maximal, but not starting, dose if limited by tolerability (confer with MM if less than half-maximal dose).
Cannot have received: investigational drug
Any investigational drug within 4 weeks or within less than five times the drug's half-life, whichever is longer, prior to Screening 1 or between Screening 1 and Day 1
Lab requirements
Kidney function
Glomerular filtration rate (GFR) <45 mL/min/1.73 m²
Liver function
Liver enzymes >3 × upper limit of normal (ULN) (ALT or AST) or bilirubin >1.5 × ULN (excepting benign conditions such as Gilbert's)
Glomerular filtration rate (GFR) <45 mL/min/1.73 m². Liver enzymes >3 × upper limit of normal (ULN) (ALT or AST) or bilirubin >1.5 × ULN (excepting benign conditions such as Gilbert's)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Arizona Clinical Trials - Pecos · Chandler, Arizona
- Arizona Clinical Trials - Broadway · Tucson, Arizona
- Ark Clinical Research - Fountain Valley · Fountain Valley, California
- Velocity Clinical Research, Huntington Park · Huntington Park, California
- Velocity Clinical Research - Gardena · La Mesa, California
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT07296484 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior investigational drug disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify