OncoMatch/Clinical Trials/NCT07296484
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Is NCT07296484 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies clofutriben for type 2 diabetes.
Treatment: clofutriben — CAPTAIN-T2D will take place in two parts. Part 1 (Screening) will evaluate patients with type 2 diabetes and elevated cortisol risk factors for trial eligibility and the presence of elevated cortisol. Participants deemed eligible from Part 1 will be randomized to either clofutriben or placebo in the double-blind (participant and investigator), dose-ranging, interventional Part 2 (Treatment).
Check if I qualifyExtracted eligibility criteria
Prior therapy
Must have received: antidiabetic medication
Treatment with stable and adequate doses of ≥2 injectable or oral ADMs. (An ADM will be deemed stable if the dose has been the same for at least 3 months prior to Screening 1 and without change between Screening 1 and Day 1) (An ADM dose will be deemed adequate if it is at or above the maximal labelled dose, or a sub-maximal, but not starting, dose if limited by tolerability (confer with MM if less than half-maximal dose).
Cannot have received: investigational drug
Any investigational drug within 4 weeks or within less than five times the drug's half-life, whichever is longer, prior to Screening 1 or between Screening 1 and Day 1
Lab requirements
Kidney function
Glomerular filtration rate (GFR) <45 mL/min/1.73 m²
Liver function
Liver enzymes >3 × upper limit of normal (ULN) (ALT or AST) or bilirubin >1.5 × ULN (excepting benign conditions such as Gilbert's)
Glomerular filtration rate (GFR) <45 mL/min/1.73 m². Liver enzymes >3 × upper limit of normal (ULN) (ALT or AST) or bilirubin >1.5 × ULN (excepting benign conditions such as Gilbert's)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Arizona Clinical Trials - Pecos · Chandler, Arizona
- Arizona Clinical Trials - Broadway · Tucson, Arizona
- Ark Clinical Research - Fountain Valley · Fountain Valley, California
- Velocity Clinical Research, Huntington Park · Huntington Park, California
- Velocity Clinical Research - Gardena · La Mesa, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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