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OncoMatch/Clinical Trials/NCT07284758

A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

Is NCT07284758 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Cemsidomide and Dexamethasone for multiple myeloma.

Phase 2RecruitingC4 Therapeutics, Inc.NCT07284758Data as of May 2026

Treatment: Cemsidomide · DexamethasoneThis is a Phase 2, open-label, single-arm, multicenter study to assess the antimyeloma activity and further characterize the safety, tolerability, PK, and PD of cemsidomide in combination with dexamethasone in participants with relapsed/refractory multiple myeloma (r/r MM).

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Prior therapy

Min 3 prior lines

Must have received: immunomodulatory drug (IKZF1/3 degrader)

must have included an immunomodulatory drug (i.e., IKZF 1/3 degrader)

Must have received: proteasome inhibitor

must have included...a proteasome inhibitor

Must have received: anti-CD38 antibody

must have included...an anti-CD38 antibody

Must have received: T-cell engager

must have included...a T-cell engager (TCE) or chimeric antigen receptor T-cell (CAR-T) therapy

Must have received: CAR-T cell therapy

must have included...a T-cell engager (TCE) or chimeric antigen receptor T-cell (CAR-T) therapy

Cannot have received: (cemsidomide)

Previously treated with cemsidomide

Lab requirements

Blood counts

Kidney function

Liver function

Subjects need to have adequate organ function.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Berenson Cancer Center · West Hollywood, California
  • START Midwest · Grand Rapids, Michigan
  • START San Antonio · San Antonio, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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