OncoMatch/Clinical Trials/NCT07282587
Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma
Is NCT07282587 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including ONC206 and ONC206: Dose 1 for advanced pheochromocytoma and paraganglioma.
Treatment: ONC206 · ONC206: Dose 1 · ONC206: Dose 2 — This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).
Check if I qualifyExtracted eligibility criteria
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: ONC206 or dordaviprone (ONC201) (ONC206, dordaviprone, ONC201)
Has previous exposure to ONC206 or dordaviprone (ONC201) from any source.
Lab requirements
Blood counts
Has laboratory test results meeting the following parameters within 14 days before the first dose of study treatment
Kidney function
Has laboratory test results meeting the following parameters within 14 days before the first dose of study treatment
Liver function
Has laboratory test results meeting the following parameters within 14 days before the first dose of study treatment
Cardiac function
No active cardiac disease/condition including: QTc >480 msec, NYHA III-IV CHF, unstable angina, acute MI, or recent arterial bypass/PTCA within 6 months
Has laboratory test results meeting the following parameters within 14 days before the first dose of study treatment; Has active cardiac disease/condition including any of the following: Corrected QT interval (QTc) >480 msec, history of documented congestive heart failure (NYHA III-IV), unstable angina, acute myocardial infarction, or arterial bypass or percutaneous transluminal coronary angioplasty within 6 months
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UCLA · Los Angeles, California
- Stanford · Palo Alto, California
- U of Colorado · Aurora, Colorado
- U of Michigan · Ann Arbor, Michigan
- Mayo-Rochester · Rochester, Minnesota
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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