OncoMatch/Clinical Trials/NCT07254585
SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma
Is NCT07254585 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including SYS6010 and Enlonstobart for head and neck squamous cell carcinoma.
Treatment: SYS6010 · Enlonstobart — This study is a n open-label, multi-center, phase II study to evaluate the efficacy and safety of SYS6010 combined with Enlonstobart in the recurrent or metastatic head and neck squamous cell carcinoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Head and Neck Squamous Cell Carcinoma
Biomarker criteria
Required: PD-L1 (CD274) positive (CPS≥1) (CPS≥1)
baseline PD-L1 positivity (CPS≥1) must be confirmed by the central laboratory; for participants who have previously received systemic antitumor treatment, there is no restriction on baseline PD-L1 expression
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Lab requirements
Blood counts
Major organ function must meet the criteria within 7 days prior to the first dose of the study intervention
Kidney function
Major organ function must meet the criteria within 7 days prior to the first dose of the study intervention
Liver function
Major organ function must meet the criteria within 7 days prior to the first dose of the study intervention
Major organ function must meet the criteria within 7 days prior to the first dose of the study intervention
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07254585 currently recruiting?
Yes, this trial is currently recruiting patients.
Does this trial require CD274?
Yes, CD274 positive (CPS≥1) is a required biomarker for enrollment.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify