OncoMatch/Clinical Trials/NCT07250269
Study of GC012F, CAR-T Therapy Targeting CD19 and BCMA in Chinese Participants With Relapsed or Refractory AL Amyloidosis
Is NCT07250269 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies GC012F for relapsed/refractory al amyloidosis.
Treatment: GC012F — This is a Phase 1b open-label, multicenter, non-randomized study of GC012F, a CD19/BCMA dual CAR T cell therapy, in adult participants with relapsed/refractory AL amyloidosis.
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Disease stage
Excluded: Stage MAYO STAGE IIIB
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: anti-plasma cell-directed therapy
need for additional therapy after at least 1 line of anti-plasma cell-directed therapy
Cannot have received: CAR-T cell therapy
Prior CAR T cell therapy directed at any target
Cannot have received: BCMA-targeting therapy
Prior BCMA-targeting therapy
Cannot have received: T cell engaging therapy
Exception: within the last 6 months
Prior treatment with any approved or investigational T cell engaging therapies (including T cell-directed bispecific or trispecific therapies) at any target within the last 6 months
Lab requirements
Cardiac function
NT-proBNP ≥ 2000 ng/L (for dose escalation portion); NT-proBNP < 2000 and > 5000 ng/L (for dose extension portion); High-sensitivity cardiac troponin T > 75 ng/L; NYHA class III or IV; Systolic blood pressure <100mmHg; Oxygen saturation < 95% on room air
NT-proBNP levels as follows: NT-proBNP ≥ 2000 ng/L (for dose escalation portion) NT-proBNP < 2000 and > 5000 ng/L (for dose extension portion) High-sensitivity cardiac troponin T > 75 ng/L NYHA class III or IV Systolic blood pressure <100mmHg Oxygen saturation < 95% on room air
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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