OncoMatch/Clinical Trials/NCT07232420
A Study of BL-M24D1 in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer and Other Solid Tumors
Is NCT07232420 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies BL-M24D1 for non small cell lung cancer.
Treatment: BL-M24D1 — This study is an open, multicenter, non-randomized phase I clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics, and preliminary efficacy of BL-M24D1 in patients with locally advanced or metastatic non-small cell lung cancer and other solid tumors.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Tumor Agnostic
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
Use of chemotherapy...within 4 weeks or 5 half-lives prior to the first dose
Cannot have received: biotherapy
Use of...biotherapy...within 4 weeks or 5 half-lives prior to the first dose
Cannot have received: immunotherapy
Use of...immunotherapy within 4 weeks or 5 half-lives prior to the first dose
Cannot have received: anthracycline
Exception: cumulative dose ≤360 mg/m² in previous (neo)adjuvant anthracycline therapy
Cumulative dose of anthracyclines >360 mg/m² in previous (neo)adjuvant anthracycline therapy
Lab requirements
Blood counts
Toxicities from prior antitumor therapy have recovered to ≤ Grade 1 as defined by NCI-CTCAE v5.0
Kidney function
Liver function
Cardiac function
No severe cardiac dysfunction, left ventricular ejection fraction ≥50%; QT interval prolongation, complete left bundle branch block, or third-degree atrioventricular block excluded
No severe cardiac dysfunction, left ventricular ejection fraction ≥50%; Organ function levels must meet the requirements; Coagulation function: international normalized ratio ≤1.5, and activated partial thromboplastin time ≤1.5 × ULN; Urine protein ≤2+ or ≤1000mg/24h
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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