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OncoMatch/Clinical Trials/NCT07228832

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Is NCT07228832 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments including Drug: Ivonescimab and Drug: Bevacizumab for metastatic colorectal cancer (crc).

Phase 3RecruitingSummit TherapeuticsNCT07228832Data as of May 2026

Treatment: Drug: Ivonescimab · Drug: BevacizumabA Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Biomarker criteria

Excluded: BRAF v600e

Disease stage

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: immunotherapy

Cannot have received: anti-angiogenic therapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Clinical Study Site · Goodyear, Arizona
  • Clinical Study Site · Beverly Hills, California
  • Clinical Study Site · Cerritos, California
  • Clinical Study Site · Corona, California
  • Clinical Study Site · Duarte, California

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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