OncoMatch

OncoMatch/Clinical Trials/NCT07227415

A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Is NCT07227415 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including PF-08634404 and Combination 1 for carcinoma, renal cell.

Phase 1/2RecruitingPfizerNCT07227415Data as of May 2026

Treatment: PF-08634404 · Combination 1 · Combination 2 — This study is testing a new medicine called PF-08634404 and how it works in adults with advanced Renal Cell Carcinoma (RCC)- a type of kidney cancer that is either locally advanced (spread to nearby tissues) or metastatic (spread to other parts of the body). The study will look at the safety of the study medicine, when given alone or with other anticancer medicines, and how this type of cancer responds to them. To join the study, participants must be adults; with locally advanced or metastatic RCC; who have not received treatment for their advanced kidney cancer. Participants will receive study medicine either alone or with other anticancer medicines. The medicine will be given through intravenous (IV) infusions, which means it will be injected directly into a vein. All treatments will take place at clinical study sites, where trained medical staff will take care of participants during and after each visit.

Check if I qualify

Extracted eligibility criteria

Cancer type

Renal Cell Carcinoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

adequate hematologic function

Kidney function

adequate renal function

Liver function

adequate hepatic function

Cardiac function

adequate cardiac function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Highlands Oncology Group · Springdale, Arkansas
  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center) · Duarte, California
  • Rocky Mountain Cancer Centers, LLP · Denver, Colorado
  • City Of Hope - Chicago · Zion, Illinois
  • Minnesota Oncology Hematology, P.A. · Minneapolis, Minnesota

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify