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OncoMatch/Clinical Trials/NCT07221500

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

Is NCT07221500 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies NX-5948 for chronic lymphocytic leukemia (cll).

Phase 2RecruitingNurix Therapeutics, Inc.NCT07221500Data as of May 2026

Treatment: NX-5948 — This is a study for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have previously received treatment with a BTK inhibitor (covalent and non-covalent) and a BCL-2 inhibitor. The main purpose of this study is to test if NX-5948 (bexobrutideg) works to treat patients with CLL/SLL. Participation could last up to 5 years, and possibly longer, if the disease does not progress.

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Extracted eligibility criteria

Cancer type

Chronic Lymphocytic Leukemia

Non-Hodgkin Lymphoma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Must have received: covalent btk inhibitor

Must have received: non-covalent btk inhibitor

Must have received: bcl-2 inhibitor

Cannot have received: btk degrader

Cannot have received: car-t cell therapy

Exception: if <1 year prior to enrollment

Cannot have received: autologous hematopoietic cell transplant

Exception: if <1 year prior to enrollment

Lab requirements

Blood counts

adequate organ and bone marrow function

Kidney function

adequate organ and bone marrow function

Liver function

adequate organ and bone marrow function

Adequate organ and bone marrow function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Colorado Blood Institute · Denver, Colorado
  • Florida Cancer Specialists · Sarasota, Florida
  • Maryland Oncology Hematology · Silver Spring, Maryland
  • Novant Health Cancer Institute · Winston-Salem, North Carolina
  • University of Cincinnati · Cincinnati, Ohio

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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