OncoMatch/Clinical Trials/NCT07193654
Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread
Is NCT07193654 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Intrathecal and Stupp regimen (oral temozolomide) for glioblastoma (gbm).
Treatment: Intrathecal · Stupp regimen (oral temozolomide) — The goal of this clinical trial is to learn if a combined treatment approach can treat glioblastoma (GBM) with ventricular invasion or meningeal metastasis in adults. The main questions it aims to answer are: Does the combined treatment of radical radiotherapy, the Stupp regimen (oral temozolomide), and intrathecal injection of thiotepa improve progression-free survival compared to standard treatment alone? Does the combined treatment improve overall survival compared to standard treatment alone? Participants will: * Undergo maximal surgical resection of the tumor； * Receive radical radiotherapy； * Take oral temozolomide according to the Stupp regimen； * Receive intrathecal injections of thiotepa。
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Disease stage
Required: Stage WHO GRADE 4 (WHO)
Grade: 4 (WHO)
Newly diagnosed WHO grade 4 brain tumor with at least one evaluable lesion, imaging suggesting ventricular or meningeal invasion
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Blood counts
Neutrophil count ≥1.5×10⁹/L, hemoglobin ≥90 g/L, platelet count ≥75×10⁹/L, PT/INR and PTT ≤1.5×ULN
Kidney function
creatinine ≤2×ULN, calculated or 24-hour urine creatinine clearance rate ≥50 mL/min
Liver function
Total bilirubin ≤1.5×ULN, AST and ALT ≤1.5×ULN, albumin ≥30 g/L
Neutrophil count≥1.5×10⁹/L, hemoglobin≥90 g/L, platelet count≥75×10⁹/L. PT/INR and PTT≤1.5×upper limit of normal. Total bilirubin≤1.5×upper limit of normal, AST and ALT≤1.5×upper limit of normal, albumin≥30 g/L, creatinine≤2×upper limit of normal, calculated or 24-hour urine creatinine clearance rate≥50 mL/min.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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