OncoMatch/Clinical Trials/NCT07189403
A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer
Is NCT07189403 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies DS9051b for advanced or metastatic adrenocortical carcinoma.
Treatment: DS9051b — This FIH study is designed to assess the safety, tolerability, and preliminary efficacy signals of DS9051b in participants with ACC and mCRPC.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Prostate Cancer
Disease stage
Required: Stage IV
advanced or metastatic
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: androgen receptor pathway inhibitor (abiraterone, enzalutamide, darolutamide, apalutamide) — cspc or crpc
Must have received: chemotherapy
Lab requirements
Blood counts
adequate organ and bone marrow function as assessed by local laboratory within 14 days prior to C1D1 as defined below. Organ and bone marrow function criteria must also be met when laboratory tests are repeated within 3 days of initiation of trial intervention as appropriate.
Kidney function
adequate organ and bone marrow function as assessed by local laboratory within 14 days prior to C1D1 as defined below. Organ and bone marrow function criteria must also be met when laboratory tests are repeated within 3 days of initiation of trial intervention as appropriate.
Liver function
adequate organ and bone marrow function as assessed by local laboratory within 14 days prior to C1D1 as defined below. Organ and bone marrow function criteria must also be met when laboratory tests are repeated within 3 days of initiation of trial intervention as appropriate.
Has adequate organ and bone marrow function as assessed by local laboratory within 14 days prior to C1D1 as defined below. Organ and bone marrow function criteria must also be met when laboratory tests are repeated within 3 days of initiation of trial intervention as appropriate.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Florida Cancer Specialists · Sarasota, Florida
- Columbia University · New York, New York
- Brown University · Providence, Rhode Island
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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