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OncoMatch/Clinical Trials/NCT07169994

A Study of YL202 in Combination With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors

Is NCT07169994 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including YL202 for and YL202 for for advanced solid tumors.

Phase 1/2RecruitingMediLink Therapeutics (Suzhou) Co., Ltd.NCT07169994Data as of May 2026

Treatment: YL202 for · YL202 forThis is a multicenter, open-label, phase Ib/II study of YL202 in combination with other anti-tumor therapies to Evaluate the Safety, Tolerability, and Efficacy in Patients with Advanced Solid Tumors

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Extracted eligibility criteria

Cancer type

Tumor Agnostic

Breast Carcinoma

Small Cell Lung Cancer

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: HER3-targeted therapy

With prior drug therapy targeting HER3 (including antibodies, antibody-drug conjugates [ADCs]), chimeric antigen receptor T-cell immunotherapy (CAR-T), and other drugs

Cannot have received: CAR-T cell therapy

With prior drug therapy targeting HER3 (including antibodies, antibody-drug conjugates [ADCs]), chimeric antigen receptor T-cell immunotherapy (CAR-T), and other drugs

Cannot have received: topoisomerase I inhibitor

Previously intolerant to topoisomerase I inhibitors or ADC therapy composed of topoisomerase I inhibitors

Cannot have received: antibody-drug conjugate

Previously intolerant to topoisomerase I inhibitors or ADC therapy composed of topoisomerase I inhibitors

Cannot have received: allogeneic bone marrow transplantation

Prior treatment with allogeneic bone marrow transplantation or solid organ transplantation

Cannot have received: solid organ transplantation

Prior treatment with allogeneic bone marrow transplantation or solid organ transplantation

Lab requirements

Blood counts

Adequate organ and bone marrow function.

Kidney function

Adequate organ and bone marrow function.

Liver function

Adequate organ and bone marrow function.

Adequate organ and bone marrow function.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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