OncoMatch/Clinical Trials/NCT07169500
Clinical Study on the Safety and Efficacy of BCMA-CART±ASCT in Treating Young Multiple Myeloma Patients
Is NCT07169500 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies CAR-T for multiple myeloma.
Treatment: CAR-T — Evaluate and compare the safety and efficacy of BCMA-CART ± ASCT in the treatment of newly diagnosed multiple myeloma (NDMM) in young patients
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Multiple Myeloma
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Cannot have received: car-t cell therapy
Cannot have received: bcma-targeted therapy
Lab requirements
Blood counts
Hemoglobin (Hb) ≥ 60 g/L; ANC ≥ 1.0 × 10^9/L (no G-CSF or other growth factors within 7 days prior to screening); ALC ≥ 0.5 × 10^9/L; Platelets ≥ 50 × 10^9/L (no platelet transfusion within 7 days prior to screening)
Kidney function
Creatinine clearance (CrCl) ≥ 40 ml/min
Liver function
Serum total bilirubin (TBIL) ≤ 1.5x ULN; ALT and AST ≤ 2.5x ULN
Cardiac function
LVEF ≥ 45%
Subjects must have adequate organ function and meet all of the following test results: Serum total bilirubin (TBIL) ≤ 1.5x ULN; ALT and AST ≤ 2.5x ULN; Creatinine clearance (CrCl) ≥ 40 ml/min; Prothrombin time (PT) ≤ 1.5x ULN, APTT < 1.5x ULN, INR < 1.5x ULN; Hemoglobin (Hb) ≥ 60 g/L; ANC ≥ 1.0 × 10^9/L (no G-CSF or other growth factors within 7 days prior to screening); ALC ≥ 0.5 × 10^9/L; Platelets ≥ 50 × 10^9/L (no platelet transfusion within 7 days prior to screening); LVEF ≥ 45%; SpO2 ≥ 92%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07169500 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior car-t cell therapy, bcma-targeted therapy disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 50 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages