OncoMatch

OncoMatch/Clinical Trials/NCT07166094

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

Is NCT07166094 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments including Rina-S and IC for endometrial cancer.

Phase 3RecruitingGenmabNCT07166094Data as of May 2026

Treatment: Rina-S · IC — The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (50:50) chance of getting either Rina-S or a chemotherapy agent as treatment in this study. The study duration will be approximately 3 years. The treatment duration will be different for every participant, but an average of 4 to 6 months is expected. All participants will receive active drug; no one will be given placebo. Participation in the study will require visits to the study site(s).

Check if I qualify

Extracted eligibility criteria

Cancer type

Endometrial Cancer

Prior therapy

Max 3 prior lines
Min 1 prior line

Must have received: platinum-based chemotherapy

Participants must have received prior platinum-based chemotherapy

Must have received: anti-PD-1 therapy

Participants must have received prior...programmed death (ligand)-1 (PD(L)-1) inhibitor, either separately or in combination

Cannot have received: antibody-drug conjugate

Exception: containing a topoisomerase 1 inhibitor

Prior therapy with an antibody-drug conjugate containing a topoisomerase 1 inhibitor

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • SMH - Sarasota - Main Campus · Sarasota, Florida
  • Emory Winship Cancer Inst. · Atlanta, Georgia
  • Emory Winship Cancer Inst. · Atlanta, Georgia
  • Emory Winship Cancer Inst./Emory Decatur Hospital · Decatur, Georgia
  • Trials365, LLC · Shreveport, Louisiana

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify