OncoMatch/Clinical Trials/NCT07158021
Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial
Is NCT07158021 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Goserelin and Leuprolide for anatomic stage i breast cancer ajcc v8.
Treatment: Goserelin · Leuprolide — This phase II trial compares leuprolide to goserelin for reducing estrogen production by the ovaries in pre- or peri-menopausal women with breast cancer. Estrogen can cause the growth of breast cancer cells. Both leuprolide and goserelin lower the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. This study compares lower dose leuprolide, higher dose leuprolide, and goserelin for their ability to suppress the function of the ovaries to produce estrogen. Both doses of leuprolide may be as safe, tolerable and/or effective as goserelin in suppressing ovarian function in pre- or peri-menopausal women with breast cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Disease stage
Required: Stage I, II, III, IV (AJCC v8)
adjuvant treatment of stage 1-3 breast cancer or for treatment of metastatic breast cancer
Prior therapy
Must have received: chemotherapy
Completion of chemotherapy, if given
Cannot have received: bilateral salpingo-oophorectomy
Prior bilateral salpingo-oophorectomy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Michigan Comprehensive Cancer Center · Ann Arbor, Michigan
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