OncoMatch/Clinical Trials/NCT07149857
A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel
Is NCT07149857 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Cilta-cel and Cyclophosphamide for multiple myeloma.
Treatment: Cilta-cel · Cyclophosphamide · Induction therapy · Fludarabine — The purpose of this study is to evaluate how well (efficacy) cilta-cel works when given with a fludarabine-free lymphodepletion regimen (a process of reducing the number of lymphocytes, a type of white blood cell in the body, typically through chemotherapy), or an alternative administration of cilta-cel infusion following a cyclophosphamide and fludarabine lymphodepletion regimen.
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: induction therapy — newly diagnosed
Participant must have received at least 3 cycles and no more than 5 cycles of induction therapy. Initially, only participants receiving triplet induction therapy with DRd or VRd will be enrolled. Only after sponsor notification, participants receiving quadruplet DVRd induction therapy may be enrolled
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Moffitt Cancer Center · Tampa, Florida
- University of Iowa Hospital and Clinics · Iowa City, Iowa
- Memorial Sloan Kettering Cancer Center · New York, New York
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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