OncoMatch/Clinical Trials/NCT07139990
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
Is NCT07139990 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1 trial studies non-drug interventions for small cell lung cancer extensive stage.
To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient responses.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Tumor Agnostic
Sarcoma
Disease stage
Required: Stage EXTENSIVE STAGE (SCLC, COHORT A), CLINICAL STAGE III/IVA (AJCC 8TH EDITION, COHORT D) (other)
Excluded: Stage METASTATIC (NODAL OR DISTANT) DISEASE (COHORT C), DISTANT METASTASIS (COHORT D)
Grade: FNCLCC grade 2 or 3 (Cohort C) (FNCLCC (Cohort C))
See cohort-specific inclusion/exclusion for details
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: chemoimmunotherapy — standard of care for extensive stage small cell lung cancer
Patient must be planned for or receiving standard of care chemoimmunotherapy. Patient must have received no more than 3 cycles by time of study enrollment.
Cannot have received: thoracic radiotherapy
Prior thoracic Radiotherapy (Cohort A)
Cannot have received: whole brain radiotherapy
Prior whole brain Radiotherapy (Cohort B)
Cannot have received: surgical resection or focal radiotherapy of a target brain metastasis
Prior surgical resection or focal radiotherapy of a target brain metastasis (Cohort B)
Cannot have received: immunotherapy
Prior immunotherapy (Cohort C)
Cannot have received: systemic chemotherapy for the study cancer
Exception: prior chemotherapy for a remote cancer is allowable
Prior systemic chemotherapy for the study cancer; prior chemotherapy for a remote cancer is allowable (Cohort D)
Cannot have received: immunotherapy for the study cancer or for a remote cancer
Prior immunotherapy for the study cancer or for a remote cancer (Cohort D)
Cannot have received: head and neck radiotherapy
Prior head and neck radiotherapy (Cohort D)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Ut Southwestern Medical Center · Dallas, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT07139990 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior thoracic radiotherapy, whole brain radiotherapy, surgical resection or focal radiotherapy of a target brain metastasis disqualifies patients from enrollment.
What disease stage is eligible?
Stage EXTENSIVE STAGE (SCLC, COHORT A) or CLINICAL STAGE III/IVA (AJCC 8TH EDITION, COHORT D) is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages