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OncoMatch/Clinical Trials/NCT07139366

Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment

Is NCT07139366 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies multiple treatments for gastritis.

Phase 4RecruitingYongquan ShiNCT07139366Data as of May 2026

Treatment: Bismuth · Esomeprazole · Tetracycline · Furazolidone · Saccharomyces Boulardii Oral PowderThis study aims at evaluating efficacy and safety of Saccharomyces boulardii combined with bismuth-containing quadruple Therapy versus bismuth-containing quadruple Therapy(bismuth#esomeprazole#tetracycline and furazolidone) in H. pylori rescue therapy. It is hypothesized that Saccharomyces boulardii combined with bismuth-containing quadruple Therapy is superior to bismuth-containing quadruple Therapy. Patients with confirmed failure of H. pylori eradication will be randomized to one of the treatments described above. At week 6 follow-up visits, a urea breath test#rapid urease test or helicobacter pylori stool antigen test will be performed to confirm eradication.

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Extracted eligibility criteria

Cancer type

Gastric Cancer

Prior therapy

Must have received: H. pylori eradication therapy

Patients who had failed H.pylori eradication therapies

Cannot have received: tetracycline or furazolidone antibiotics for H. pylori eradication (tetracycline, furazolidone)

Patients who have previously used tetracycline and furazolidone antibiotics to eradicate infection with H. pylori.

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