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OncoMatch/Clinical Trials/NCT07138755

The Efficacy and Safety of the Combination of PD-1 With Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients

Is NCT07138755 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Experimental for nsclc.

Phase 2RecruitingThe Third Xiangya Hospital of Central South UniversityNCT07138755Data as of Jun 2026Location: China

Treatment: ExperimentalTo evaluate the Efficacy and Safety of the Combination of Sintilimab With Platinum-doublet Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients

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Extracted eligibility criteria

Treatments studied

Other

Experimental

Cancer type

Non-Small Cell Lung Carcinoma

Biomarker criteria

Required: ALK wild-type

Required: EGFR wild-type

Required: HER2 (ERBB2) wild-type

Required: MET wild-type

Required: ROS1 wild-type

Disease stage

Required: Stage III

Demographics

Ages ≤ 75

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: systematic anti-tumor treatment

No previous systematic anti-tumor treatment or chest radiotherapy for NSCLC

Cannot have received: chest radiotherapy

No previous systematic anti-tumor treatment or chest radiotherapy for NSCLC

Cannot have received: thoracic radiotherapy

Previously received local treatments for tumor lesions such as thoracic radiotherapy and radiofrequency ablation

Cannot have received: radiofrequency ablation

Previously received local treatments for tumor lesions such as thoracic radiotherapy and radiofrequency ablation

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT07138755 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

Does this trial require ALK?

Yes, ALK wild-type is a required biomarker for enrollment.

Does this trial require EGFR?

Yes, EGFR wild-type is a required biomarker for enrollment.

Does this trial require ERBB2?

Yes, ERBB2 wild-type is a required biomarker for enrollment.

What disease stage is eligible?

Stage III is required.

Is there an age limit?

Yes. Patients must be 75 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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