OncoMatch/Clinical Trials/NCT07107126
Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes
Is NCT07107126 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies RPT1G for acute myeloid leukemia.
Treatment: RPT1G — The main goals of this study are to learn if RPT1G is safe and tolerable and to determine the best dose and schedule of RPT1G for patients with relapsed or refractory acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS).
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: standard of care therapy
have received appropriate standard of care therapy, in the opinion of the investigator or declined receipt of these
Cannot have received: radiotherapy
Radiotherapy <14 days prior to the first day of RPT1G administration
Lab requirements
Kidney function
creatinine clearance >50 mL/min (Cockcroft-Gault equation, CLIA certified local laboratory)
Liver function
AST ≤2.5 x ULN, ALT ≤2.5 x ULN, and total bilirubin <2 x ULN (exceptions for Gilbert's syndrome and disease-related elevation possible)
Hepatic: AST ≤2.5 x ULN, ALT ≤2.5 x ULN, and total bilirubin <2 x ULN (except for study patients with known Gilbert's where 1.5 x UL of the subject's baseline or in the case of suspected Gilbert's syndrome where a maximum total bilirubin level of 4.0 mg/dL is acceptable) for the local laboratory. If due to disease, higher values may be approved after discussion with medical monitor. Renal: Adequate renal function as defined by calculated creatinine clearance >50 mL/min for the CLIA certified local laboratory. Creatinine clearance must be calculated by Cockcroft-Gault equation.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Memorial Sloan Kettering Cancer Center · New York, New York
- MD Anderson Cancer Center · Houston, Texas
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