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OncoMatch/Clinical Trials/NCT07095517

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

Is NCT07095517 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies Tirzepatide for colorectal cancer prevention.

Phase 1RecruitingMassachusetts General HospitalNCT07095517Data as of May 2026

Treatment: TirzepatideThis research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study.

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Prior therapy

Must have received:

Underwent a screening or surveillance colonoscopy within the prior 9 months

Cannot have received: incretin mimetic therapy

Participants who have ever taken incretin mimetic therapies

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Massachusetts General Hospital Cancer Center · Boston, Massachusetts

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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