OncoMatch/Clinical Trials/NCT07085559

Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research

Is NCT07085559 recruiting? Yes, currently enrolling (May 2026). This Early Phase 1 trial studies Metabolically Armed BCMA CAR-T cells. for multiple myeloma (mm).

Early Phase 1RecruitingAnhui Provincial HospitalNCT07085559Data as of May 2026

Treatment: Metabolically Armed BCMA CAR-T cells. — A Study of Metabolically Armed BCMA CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Plasma Cell Neoplasms.

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Biomarker criteria

Required: BCMA (TNFRSF17) cell membrane BCMA expression

Evidence of cell membrane BCMA expression, as determined by a validated immunohistochemistry (IHC) or flow cytometry of tumor tissue.

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 3 prior lines

Must have received: proteasome inhibitor

at least 3 prior lines of therapy (including chemotherapy based on proteasome inhibitors and immunomodulatory agents)

Must have received: immunomodulatory agent

at least 3 prior lines of therapy (including chemotherapy based on proteasome inhibitors and immunomodulatory agents)

Cannot have received: hematopoietic stem cell transplant

Exception: HSCT within 2 months prior to the start of infusion of Meta10-BCMA

Any hematopoietic stem cell transplant(HSCT) within 2 months prior to the start of infusion of Meta10-BCMA

Lab requirements

Blood counts

ANC ≥1×10^9 /L; hemoglobin ≥70 g/L; platelets ≥50×10^9 /L; ALC ≥0.3×10^9 /L

Kidney function

Serum creatinine ≤2.5×ULN, or CrCl ≥ 60 ml/min

Liver function

ALT and AST ≤ 2.5×ULN; total serum bilirubin ≤ 1.5×ULN

Cardiac function

LVEF ≥ 50%

Subjects should have adequate organ function: ... CBC ... ALT and AST ≤ 2.5×ULN; total serum bilirubin ≤ 1.5×ULN ... Serum creatinine ≤2.5×ULN, or CrCl ≥ 60 ml/min ... LVEF ≥ 50%

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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