OncoMatch

OncoMatch/Clinical Trials/NCT07081646

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Is NCT07081646 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies AZD0120 for relapsed al amyloidosis.

Phase 1/2RecruitingAlexion Pharmaceuticals, Inc.NCT07081646Data as of May 2026

Treatment: AZD0120Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Disease stage

Excluded: Stage MAYO STAGE IIIB

Measurable hematologic disease: dFLC > 20 mg/L or serum M-protein > 5g/L; Mayo Stage IIIb AL amyloidosis [excluded]

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 1 prior line

Must have received: anti-plasma cell-directed therapy

Relapsed disease or refractory disease defined as a need for additional therapy after at least 1 line of anti-plasma cell-directed therapy.

Cannot have received: CAR-T cell therapy

Prior CAR T cell therapy directed at any target

Cannot have received: BCMA-targeting therapy

Prior BCMA-targeting therapy

Cannot have received: T cell engaging therapy

Prior treatment with any FDA approved or investigational T cell engaging therapies (including T cell-directed bispecific or trispecific therapies) at any target within the last 6 months.

Lab requirements

Cardiac function

NYHA class III or IV excluded; Systolic blood pressure <100mmHg excluded; Oxygen saturation <95% on room air excluded

Oxygen saturation < 95% on room air; Systolic blood pressure <100mmHg; NYHA class III or IV

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Research Site · Phoenix, Arizona
  • Research Site · San Francisco, California
  • Research Site · Tampa, Florida
  • Research Site · Boston, Massachusetts
  • Research Site · Detroit, Michigan

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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