OncoMatch/Clinical Trials/NCT07081646
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Is NCT07081646 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies AZD0120 for relapsed al amyloidosis.
Treatment: AZD0120 — Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Disease stage
Excluded: Stage MAYO STAGE IIIB
Measurable hematologic disease: dFLC > 20 mg/L or serum M-protein > 5g/L; Mayo Stage IIIb AL amyloidosis [excluded]
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: anti-plasma cell-directed therapy
Relapsed disease or refractory disease defined as a need for additional therapy after at least 1 line of anti-plasma cell-directed therapy.
Cannot have received: CAR-T cell therapy
Prior CAR T cell therapy directed at any target
Cannot have received: BCMA-targeting therapy
Prior BCMA-targeting therapy
Cannot have received: T cell engaging therapy
Prior treatment with any FDA approved or investigational T cell engaging therapies (including T cell-directed bispecific or trispecific therapies) at any target within the last 6 months.
Lab requirements
Cardiac function
NYHA class III or IV excluded; Systolic blood pressure <100mmHg excluded; Oxygen saturation <95% on room air excluded
Oxygen saturation < 95% on room air; Systolic blood pressure <100mmHg; NYHA class III or IV
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Research Site · Phoenix, Arizona
- Research Site · San Francisco, California
- Research Site · Tampa, Florida
- Research Site · Boston, Massachusetts
- Research Site · Detroit, Michigan
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify