OncoMatch/Clinical Trials/NCT07076485
Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer
Is NCT07076485 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for breast cancer.
To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Disease stage
Required: Stage PT0-T4B N0-N3A, CT0-T4B N0-N2A, CT0-T4B N1-N3A/B/C, T0-T2 N0-N2A, T0-T3 N0-N2A, T0-T4D N0-N3C
pathologic stage pT0-T4b N0-N3a; clinical stage cT0-T4b N0-N2a; clinical stage cT0-T4b N1-N3a/b/c; pathologic stage T0-T2 N0-N2a; clinical stage T0-T3 N0-N2a; pathologic stage T0-T4d N0-N3c; clinical stage T0-T4d N0-N3c
Prior therapy
Must have received: surgery — upfront or after neoadjuvant chemotherapy
No more than 12 weeks have elapsed since final breast/lymph node surgery for patients treated with surgery alone or neoadjuvant chemotherapy
Must have received: cytotoxic chemotherapy — adjuvant
No more than 12 weeks have elapsed since final cytotoxic chemotherapy for patients who received adjuvant chemotherapy
Cannot have received: therapeutic radiation overlapping with the index breast or nodal basins
History of therapeutic radiation overlapping with the index breast or nodal basins that require radiation therapy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Cooper Hospital University Medical Center · Voorhees Township, New Jersey
- The University of Texas M. D. Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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