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OncoMatch/Clinical Trials/NCT07076121

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Is NCT07076121 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments including BMS-986504 and Gemcitabine for pancreatic ductal adenocarcinoma.

Phase 2/3RecruitingBristol-Myers SquibbNCT07076121Data as of May 2026

Treatment: BMS-986504 · Gemcitabine · Nab-paclitaxelThe purpose of this study is to assess the safety and efficacy of BMS-986504, a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination with nab-p/gem, in participants with untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC) with homozygous methylthioadenosine phosphorylase (MTAP) deletion.

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Extracted eligibility criteria

Cancer type

Pancreatic Cancer

Biomarker criteria

Required: MTAP homozygous deletion

Evidence of homozygous methylthioadenosine phosphorylase (MTAP) deletion detected in tumor tissue

Required: MTAP loss

Evidence of...MTAP loss detected in tumor tissue

Disease stage

Metastatic disease required

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Local Institution - 0142 · Phoenix, Arizona
  • Local Institution - 0365 · Tucson, Arizona
  • Highlands Oncology Group · Springdale, Arkansas
  • Scripps Green Hospital · La Jolla, California
  • Local Institution - 0157 · San Francisco, California

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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